Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8843072 | 0.90 | NPC1 (0.43) | NPC1SMN1; SMN2ALDH1A1POLBGAA | |
| SCHEMBL4849251 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1GAAMEN1MAPT | |
| SCHEMBL3959553 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1GAAMEN1MAPT | |
| SCHEMBL4848662 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1GAAMEN1MAPT | |
| SCHEMBL8843351 | 0.72 | POLB (0.44) | ALDH1A1POLBGAATACR1MAPT | |
| SCHEMBL17007846 | 0.72 | GHSR (0.59) | NPC1GHSR | |
| SCHEMBL8843065 | 0.70 | ALDH1A1 (0.40) | ALDH1A1POLBGAATACR1 | |
| SCHEMBL4890080 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2APKM | |
| SCHEMBL4848544 | 0.70 | CTSA (0.49) | NPC1SMN1; SMN2ALDH1A1POLBTSHR | |
| SCHEMBL4877736 | 0.70 | CTSA (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672615-A | MATRIX-DEGRADING METALLOPROTEINASE INHIBITORS | NOVARTIS CORPORATION (US) | 1997-09-30 | — | — | US | disclosed |