Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8844088 | 1.00 | HTR1A (0.32) | HTR1ADRD2PSMB8 | |
| SCHEMBL9274799 | 0.90 | HTR1A (0.33) | HTR1ADRD2 | |
| SCHEMBL8844268 | 0.89 | HTR1A (0.34) | HTR1ADRD2 | |
| Tivirapine SCHEMBL3145162 | 0.86 | HTR1A (0.31) | HTR1ADRD2 | |
| Tivirapine SCHEMBL377308 | 0.86 | HTR1A (0.31) | HTR1ADRD2 | |
| Tivirapine SCHEMBL8844208 | 0.85 | HTR1A (0.31) | HTR1ADRD2 | |
| SCHEMBL9695807 | 0.84 | HTR1A (0.30) | HTR1ADRD2 | |
| SCHEMBL7905545 | 0.84 | HTR1A (0.32) | HTR1ADRD2 | |
| SCHEMBL8844204 | 0.83 | PSMB8 (0.33) | HTR1ADRD2PSMB8 | |
| SCHEMBL8844142 | 0.82 | HTR1A (0.32) | HTR1ADRD2PSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599982-A | Process for preparing enantiomerically pure imidazo[4,5,1-JK][1,4]-benzodiazepin-2(1H)-thiones | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-02-04 | — | — | US | disclosed |
| US-5543570-A | Intermediates for preparing enantiomerically pure imidazo[4,5,1-JK][1,4]-benzodiazepin-2-(1H)-thiones | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-08-06 | — | — | US | disclosed |
| US-5463049-A | Process for preparing enantiomerically pure imidazo[4,5,1-JK][1,4]-benzodiazepin-2(1H)-thiones | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-31 | — | — | US | disclosed |