SCHEMBL884443

SCHEMBL884443

CCOC(=O)C(=[N+]=[N-])C(=O)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.59
MAPT P10636 2/20 0.59
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CES2 O00748 3/20 0.44
CES1 P23141 3/20 0.44
NPC1 O15118 1/20 0.44
CYP19A1 P11511 2/20 0.42
GLA P06280 1/20 0.41
FNTA P49354 1/20 0.41
FNTB P49356 1/20 0.41
LMNA P02545 1/20 0.41
TSHR P16473 1/20 0.41
ATM Q13315 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28353412 0.87 CES2 (0.47) ALDH1A1MAPTKMT2ASMN1; SMN2CES2
SCHEMBL28918242 0.85 TSHR (0.46) ALDH1A1MAPTSMN1; SMN2CES2CES1
SCHEMBL22230717 0.84 MAPT (0.48) ALDH1A1MAPTKMT2AMEN1CES2
SCHEMBL884596 0.83 CES2 (0.50) ALDH1A1MAPTSMN1; SMN2CES2CES1
SCHEMBL28349714 0.83 CES2 (0.50) ALDH1A1MAPTKMT2AMEN1SMN1; SMN2
SCHEMBL11769570 0.81 KMT2A (0.48) ALDH1A1MAPTKMT2AMEN1SMN1; SMN2
SCHEMBL97859 0.81 ALDH1A1 (0.73) ALDH1A1MAPTKMT2AMEN1SMN1; SMN2
SCHEMBL900466 0.80 ALDH1A1 (0.54) ALDH1A1MAPTKMT2AMEN1SMN1; SMN2
SCHEMBL7699081 0.80 CES1 (0.50) ALDH1A1MAPTKMT2AMEN1SMN1; SMN2
Water SCHEMBL27483870 0.79 ALDH1A1 (0.71) ALDH1A1MAPTKMT2AMEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112480049-B Synthesis method of indenone [1,2-c ] furan compound 河南师范大学 2023-09-08 CN claimed
CN-112679348-B Synthetic method of 3-arylformylindenone-2-formate compound 河南师范大学 2023-09-05 CN claimed
CN-114315696-A Synthesis method of 5-acyl aromatic ring carbazole compound 河南师范大学 2022-04-12 CN claimed
CN-112679348-A Synthetic method of 3-arylformyl indanone-2-formate compound 河南师范大学 2021-04-20 CN claimed
CN-112480049-A Synthetic method of indeno [1,2-c ] furan compound 河南师范大学 2021-03-12 CN claimed
WO-2008089005-A2 RENIN INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-07-24 WO claimed
CN-114315696-B Synthesis method of 5-acyl aryl cyclocarbazole compound 河南师范大学 2023-12-01 CN disclosed
CN-112480049-B Synthesis method of indenone [1,2-c ] furan compound 河南师范大学 2023-09-08 CN disclosed
CN-112480049-B Synthesis method of indenone [1,2-c ] furan compound 河南师范大学 2023-09-08 CN disclosed
CN-112679348-B Synthetic method of 3-arylformylindenone-2-formate compound 河南师范大学 2023-09-05 CN disclosed
CN-112679348-B Synthetic method of 3-arylformylindenone-2-formate compound 河南师范大学 2023-09-05 CN disclosed
CN-110105305-B Transition metal catalyzed C-H activation/cyclization synthesis 1,2-benzothiazine derivative green synthesis method 四川大学 2023-01-06 CN disclosed
CN-110724094-B Quinoline compound and synthesis method thereof 陕西科技大学 2022-06-14 CN disclosed
US-RE36832-E AN ANTICHOLESTEROL AGENT TREATING HYPERCHOLESTEROLEMIA NIHON NOHYAKU CO., LTD (JP) 2000-08-22 US disclosed
EP-0613894-B1 N-Heteroaryl-N'-phenylurea derivatives, their production and use NIHON NOHYAKU CO LTD (JP) 1999-05-06 EP disclosed
US-5756689-A SENSITIZERS; COMPOUNDS STABILIZED BY CERTAIN FUNCTIONAL GROUPS ADJACENT TO THE DIAZO SUBSTITUENT MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-05-26 US disclosed
US-5691098-A WITH STABILIZING ELECTRON WITHDRAWING GROUP MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-11-25 US disclosed
EP-0799716-A2 Diazo compounds for laser-induced mass transfer imaging materials MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-10-08 EP disclosed
US-5464863-A Anticholesterol agents NIHON NOHYAKU CO., LTD. (JP) 1995-11-07 US disclosed
EP-0613894-A1 N-Heteroaryl-N'-phenylurea derivatives, their production and use NIHON NOHYAKU CO., LTD. (JP) 1994-09-07 EP disclosed