Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1764242 | 0.96 | SIGMAR1 (0.49) | SIGMAR1HTR1AHTR7MEN1CYP1A2 | |
| SCHEMBL8844567 | 0.88 | SIGMAR1 (0.62) | SIGMAR1HTR1AHTR7MEN1CYP1A2 | |
| SCHEMBL1764226 | 0.88 | SIGMAR1 (0.46) | SIGMAR1HTR1AHTR7MEN1CYP1A2 | |
| SCHEMBL8845329 | 0.85 | SIGMAR1 (0.48) | SIGMAR1HTR1AHTR7MEN1CYP1A2 | |
| SCHEMBL1764370 | 0.85 | SIGMAR1 (0.61) | SIGMAR1HTR1AHTR7MEN1CYP1A2 | |
| SCHEMBL4102464 | 0.81 | SIGMAR1 (0.43) | SIGMAR1HTR1AHTR7MEN1CYP1A2 | |
| SCHEMBL8844795 | 0.80 | POLB (0.47) | SIGMAR1CHRM1DRD2CHRM2CHRM4 | |
| SCHEMBL8844660 | 0.79 | SIGMAR1 (0.82) | SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL8844968 | 0.78 | SIGMAR1 (0.41) | SIGMAR1HTR1AHTR7MEN1CYP1A2 | |
| SCHEMBL1764174 | 0.77 | SIGMAR1 (0.43) | SIGMAR1CHRM1DRD2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656633-A | Carbostyril derivatives and pharmaceutical compositions containing the same for use as a disturbance-of-consciousness improving agent, central nervous system stimulant or sigma receptor agonist | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5556857-A | SIGMA RECEPTOR AGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0512525-B1 | Carbostyril derivatives and pharmaceutical compositions containing the same for use as a disturbance-of-consciousness improving agent, central nervous system stimulant or sigma receptor agonist | OTSUKA PHARMA CO LTD (JP) | 1994-11-30 | — | — | EP | disclosed |
| EP-0512525-A1 | Carbostyril derivatives and pharmaceutical compositions containing the same for use as a disturbance-of-consciousness improving agent, central nervous system stimulant or sigma receptor agonist | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |