Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4102464 | 0.84 | SIGMAR1 (0.43) | SIGMAR1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL8844806 | 0.82 | NOTUM (0.39) | DRD2DRD4DRD3NOTUM | |
| SCHEMBL8844567 | 0.81 | SIGMAR1 (0.62) | SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL8844968 | 0.81 | SIGMAR1 (0.41) | SIGMAR1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL1764174 | 0.80 | SIGMAR1 (0.43) | SIGMAR1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL8844575 | 0.80 | SIGMAR1 (0.50) | SIGMAR1DRD2DRD4DRD3CHRM2 | |
| SCHEMBL8845329 | 0.78 | SIGMAR1 (0.48) | SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL4091274 | 0.77 | DRD2 (0.63) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL1764370 | 0.77 | SIGMAR1 (0.61) | SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL8845394 | 0.77 | TSHR (0.44) | SIGMAR1CHRM1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656633-A | Carbostyril derivatives and pharmaceutical compositions containing the same for use as a disturbance-of-consciousness improving agent, central nervous system stimulant or sigma receptor agonist | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5556857-A | SIGMA RECEPTOR AGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0512525-B1 | Carbostyril derivatives and pharmaceutical compositions containing the same for use as a disturbance-of-consciousness improving agent, central nervous system stimulant or sigma receptor agonist | OTSUKA PHARMA CO LTD (JP) | 1994-11-30 | — | — | EP | disclosed |
| EP-0512525-A1 | Carbostyril derivatives and pharmaceutical compositions containing the same for use as a disturbance-of-consciousness improving agent, central nervous system stimulant or sigma receptor agonist | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |