Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8844956 | 1.00 | HPGD (0.57) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL3739640 | 0.84 | CYP1A1 (0.56) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL3739643 | 0.84 | CYP1A1 (0.56) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL8844762 | 0.80 | ERN1 (0.59) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL17391853 | 0.80 | HPGD (0.56) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL17391855 | 0.80 | HPGD (0.56) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL11646840 | 0.75 | LTA4H (0.61) | LMNAHTTALDH1A1MEN1KMT2A | |
| SCHEMBL2160891 | 0.75 | HPGD (0.69) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL2420718 | 0.75 | HPGD (0.69) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL30210927 | 0.75 | HPGD (0.69) | HPGDLMNAHTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602151-A | ADMINISTERING TO MAMMALS TO REDUCE SERUM CHOLESTEROL LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| US-5512565-A | REDUCE CHOLESTEROL ABSORPTION IN MAMMALS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-30 | — | — | US | disclosed |
| US-5391571-A | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0428385-A1 | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-22 | — | — | EP | disclosed |