Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.61 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.61 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.61 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.61 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2160888 | 1.00 | HPGD (0.69) | HPGDLMNAHTTALDH1A1GRIN2D | |
| SCHEMBL2420718 | 1.00 | HPGD (0.69) | HPGDLMNAHTTALDH1A1GRIN2D | |
| SCHEMBL30210927 | 1.00 | HPGD (0.69) | HPGDLMNAHTTALDH1A1GRIN2D | |
| SCHEMBL2186863 | 0.84 | HPGD (0.56) | HPGDLMNAHTTALDH1A1GRIN2D | |
| SCHEMBL2186861 | 0.84 | HPGD (0.56) | HPGDLMNAHTTALDH1A1GRIN2D | |
| SCHEMBL10889665 | 0.83 | LMNA (0.51) | HPGDLMNAHTTALDH1A1GRIN2D | |
| SCHEMBL17550790 | 0.82 | CA12 (0.70) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL2161928 | 0.82 | LMNA (0.62) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL6822726 | 0.82 | CA12 (0.70) | HPGDLMNAHTTALDH1A1MAPT | |
| SCHEMBL6822725 | 0.82 | CA12 (0.70) | HPGDLMNAHTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070114155-A1 | Hydrotreating and/or hydrocracking catalyst of hydrocarbons and preparation thereof | TOTAL RAFFINAGE FRANCE (FR) | 2007-05-24 | — | — | US | claimed |
| CN-1845789-A | Hydrotreating and/or hydrocracking catalyst of hydrocarbons and preparation thereof | TOTAL FRANCE (FR) | 2006-10-11 | — | — | CN | claimed |
| WO-1998005630-A1 | PROCESS FOR THE PREPARATION OF ORGANIC NITRILES | ALLIEDSIGNAL INC. (US) | 1998-02-12 | — | — | WO | claimed |
| US-12612409-B2 | Pyrrolopyrimidines as CFTR potentiators | CYSTIC FIBROSIS FOUNDATION (US) | 2026-04-28 | — | — | US | disclosed |
| EP-4424311-A2 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation (US) | 2024-09-04 | — | — | EP | disclosed |
| EP-3541390-B1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-114957123-B | 3- (difluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof | 浙江工业大学 | 2023-11-28 | — | — | CN | disclosed |
| CN-114957124-B | 3- (trifluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof | 浙江工业大学 | 2023-11-07 | — | — | CN | disclosed |
| US-20230250100-A1 | Pyrrolopyrimidines as CFTR Potentiators | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. | 2023-08-10 | — | — | US | disclosed |
| CN-114773276-B | Pyrithiobac-sodium aldoxime ester herbicide and preparation method thereof | 常州大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-116236478-A | Application of aromatic heterocyclic formamide compound | 浙江大学 | 2023-06-09 | — | — | CN | disclosed |
| US-4769472-A | Intermediate thieno-isoxazoles and -pyrazoles and 5-benzoyl-4-bromothiophenes | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-09-06 | — | — | US | disclosed |
| US-4728651-A | SYSTEMIC OR OCULAR | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0221414-A1 | Antihypertensive thieno-isoxazoles and -pyrazoles, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-05-13 | — | — | EP | disclosed |
| EP-0112524-B1 | TRICHLOROACRYLOYL OXIME DERIVATIVES | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1986-05-28 | — | — | EP | disclosed |
| US-4581365-A | Trichloroacryloyl oxime fungicides | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1986-04-08 | — | — | US | disclosed |
| EP-0112524-A1 | Trichloroacryloyl oxime derivatives | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1984-07-04 | — | — | EP | disclosed |
| US-3983246-A | N-(sulfonyloxy) benzimidoyl halides as bactericidal or fungicidal agents | FMC CORPORATION (US) | 1976-09-28 | — | — | US | disclosed |
| US-3941832-A | Oxime ethers and pesticidal preparations containing them | CIBA-GEIGY AG (CH) | 1976-03-02 | — | — | US | disclosed |
| US-3941839-A | HERBICIDE | CIBA-GEIGY AG (CH) | 1976-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230250100-A1 | Pyrrolopyrimidines as CFTR Potentiators | CFTR, P2RX1, P2RX5 | HPGD 1724/4885LMNA 4857/4885HTT 4329/4885 |
| US-12612409-B2 | Pyrrolopyrimidines as CFTR potentiators | CFTR, CLCN2, SLC26A3 | HPGD 1081/4885LMNA 4742/4885HTT 3571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.