Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | DRD3 | P35462 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574411 | 1.00 | DRD2 (0.54) | DRD2DRD3MAPTNFKB1THPO | |
| Hydrochloric Acid SCHEMBL10577359 | 0.98 | DRD2 (0.52) | DRD2DRD3MAPTNFKB1THPO | |
| Hydrochloric Acid SCHEMBL10487255 | 0.98 | DRD2 (0.52) | DRD2DRD3MAPTNFKB1THPO | |
| SCHEMBL10487375 | 0.90 | DRD2 (0.48) | DRD2DRD3MAPTNFKB1THPO | |
| SCHEMBL18134266 | 0.81 | MAPT (0.75) | DRD2DRD3MAPTNFKB1THPO | |
| SCHEMBL10487367 | 0.81 | DRD2 (0.52) | DRD2DRD3MAPTNFKB1THPO | |
| SCHEMBL19816809 | 0.80 | MAPT (0.58) | DRD2DRD3MAPTNFKB1THPO | |
| SCHEMBL10487267 | 0.79 | DRD2 (0.44) | DRD2DRD3MTNR1AMTNR1BPRKCI | |
| SCHEMBL10577554 | 0.76 | DRD2 (0.68) | DRD2DRD3MTNR1AMTNR1B | |
| SCHEMBL10487260 | 0.75 | DRD2 (0.46) | DRD2DRD3MTNR1AMTNR1BPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863951-A | ANTIDEPRESSANTS, ANTIAGRESSIVES, DOPAMINERGIC PROPERTIES | ADIR ET CIE (FR) | 1989-09-05 | — | — | US | claimed |
| US-5665765-A | TREATMENT OF PARKINSON'S DISEASE, MEMORY DISORDERS, DISORDERS ASSOCIATED WITH DRUG ABUSE, DEPRESSION, AND PSYCHOTIC STATES | ADIR ET COMPAGNIE (FR) | 1997-09-09 | — | — | US | disclosed |
| US-4885373-A | AMINE DERVIVATIVES USED AS ANTIDEPRESSANT AND DOPAMINERGIC STIMULANTS | ADIR ET CIE (FR) | 1989-12-05 | — | — | US | disclosed |
| US-4874878-A | CHEMICAL INTERMEDIATES FOR ANTIDEPRESSANTS | ADIR ET CIE (FR) | 1989-10-17 | — | — | US | disclosed |
| US-4863951-A | ANTIDEPRESSANTS, ANTIAGRESSIVES, DOPAMINERGIC PROPERTIES | ADIR ET CIE (FR) | 1989-09-05 | — | — | US | disclosed |
| US-4851429-A | ANTIDEPRESSANT, TRANQUILIZERS | ADIR ET CIE (FR) | 1989-07-25 | — | — | US | disclosed |