Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437589 | 0.89 | PDE3B (0.39) | PDE3BPDE3AGSK3BCDK5CDK5R1 | |
| SCHEMBL7272043 | 0.87 | PDE3B (0.43) | PDE3BPDE3AGSK3BCDC7HPGD | |
| Fumaric Acid SCHEMBL9103152 | 0.80 | PDE3B (0.40) | PDE3BPDE3ACDK5CDK5R1ITK | |
| SCHEMBL7270893 | 0.77 | CYP1A2 (0.41) | PDE3BPDE3AHPGDADORA1KDM4E | |
| SCHEMBL7269315 | 0.75 | PDE3B (0.49) | PDE3BPDE3AGSK3BCDK5CDC7 | |
| SCHEMBL9360794 | 0.73 | ELANE (0.40) | KDM4CHPGDPBRM1ALDH1A1 | |
| SCHEMBL7415425 | 0.71 | ELANE (0.44) | HPGDPBRM1KDM4ENPC1ALDH1A1 | |
| SCHEMBL11225665 | 0.70 | PDE3B (0.57) | PDE3BPDE3AGSK3BCDK5CDK5R1 | |
| SCHEMBL10771601 | 0.70 | PDE4A (0.53) | PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7278194 | 0.68 | NOTUM (0.45) | PDE3BPDE3AGSK3BCDC7NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2773 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230285556-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | OMEROS CORPORATION | 2023-09-14 | — | — | US | claimed |
| WO-2023039578-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | OMEROS CORPORATION (US) | 2023-03-16 | — | — | WO | claimed |
| US-8114152-B2 | Stent coating | ICON INTERVENTIONAL SYSTEMS, INC. (US) | 2012-02-14 | — | — | US | claimed |
| US-20090062904-A1 | STENT COATING | ICON INTERVENTIONAL SYSTEMS, INC. | 2009-03-05 | — | — | US | claimed |
| EP-1738759-A1 | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same | SuperGen, Inc. (US) | 2007-01-03 | — | — | EP | claimed |
| US-20050118180-A1 | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same | SUPERGEN, INC. | 2005-06-02 | — | — | US | claimed |
| EP-0783292-B1 | INHIBITION OF HAIR GROWTH | GILLETTE CO (US) | 2003-11-19 | — | — | EP | claimed |
| EP-1276479-A2 | INHIBITION OF ABNORMAL CELL PROLIFERATION WITH CAMPTOTHECIN AND COMBINATIONS INCLUDING THE SAME | SuperGen, Inc. (US) | 2003-01-22 | — | — | EP | claimed |
| US-20020111362-A1 | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same | SUPERGEN, INC. | 2002-08-15 | — | — | US | claimed |
| WO-2001080843-A2 | INHIBITION OF ABNORMAL CELL PROLIFERATION WITH CAMPTOTHECIN AND COMBINATIONS INCLUDING THE SAME | SUPERGEN, INC. (US) | 2001-11-01 | — | — | WO | claimed |
| EP-0539575-B1 | INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES | MERRELL PHARMA INC (US) | 1997-07-23 | — | — | EP | claimed |
| EP-0783292-A1 | INHIBITION OF HAIR GROWTH | HANDELMAN, Joseph H. (US) | 1997-07-16 | — | — | EP | claimed |
| US-5610171-A | Inhibition of metastasis in patients having cancer with pyridyloxazole-2-ones | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-11 | — | — | US | claimed |
| US-5554608-A | INHIBITOR OF PROTEIN KINASE C | GILLETTE COMPANY, THE, A DELAWARE CORPORATION | 1996-09-10 | — | — | US | claimed |
| WO-1996009806-A2 | INHIBITION OF HAIR GROWTH | HANDELMAN, JOSEPH, H. (US) | 1996-04-04 | — | — | WO | claimed |
| WO-1993010778-A1 | INHIBITION OF ANGIOGENESIS WITH PYRIDINYLOXAZOLE-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-10 | — | — | WO | claimed |
| EP-0539575-A1 | INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES. | MERRELL DOW PHARMA (US) | 1993-05-05 | — | — | EP | claimed |
| WO-1992020337-A2 | INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-11-26 | — | — | WO | claimed |
| EP-0222358-B1 | CARDIOTONIC HETEROCYCLIC OXAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-17 | — | — | EP | claimed |
| EP-0222358-A1 | Cardiotonic heterocyclic oxazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-05-20 | — | — | EP | claimed |