Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846 | 0.77 | PDE3B (0.46) | PDE3BPDE3ASMN1; SMN2ADORA1KDM4E | |
| SCHEMBL9361685 | 0.73 | PDE10A (0.44) | ELANE | |
| SCHEMBL7437589 | 0.72 | PDE3B (0.39) | PDE3BPDE3AADORA1HPGD | |
| SCHEMBL9360794 | 0.67 | ELANE (0.40) | CYP1A2CYP3A4CYP2C9CYP2C19ELANE | |
| SCHEMBL21692157 | 0.66 | ASIC3 (0.65) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5MKNK1 | |
| SCHEMBL9365338 | 0.66 | PARP1 (0.43) | SMN1; SMN2TGFBR1ELANEKDM4ENPC1 | |
| SCHEMBL7272043 | 0.66 | PDE3B (0.43) | CYP1A2PDE3BPDE3ACYP2C19TGFBR1 | |
| SCHEMBL29578028 | 0.65 | ASIC3 (0.63) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5MKNK1 | |
| SCHEMBL912763 | 0.65 | ASIC3 (0.63) | MAPKAPK2CDK1MAPKAPK3MAPKAPK5MKNK1 | |
| SCHEMBL9360294 | 0.64 | NPC1 (0.49) | CYP1A2CYP3A4SMN1; SMN2CYP2C19TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539575-B1 | INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES | MERRELL PHARMA INC (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5610171-A | Inhibition of metastasis in patients having cancer with pyridyloxazole-2-ones | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0539575-A1 | INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES. | MERRELL DOW PHARMA (US) | 1993-05-05 | — | — | EP | disclosed |
| US-5182293-A | Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-01-26 | — | — | US | disclosed |
| WO-1992020337-A2 | INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-11-26 | — | — | WO | disclosed |
| US-5063238-A | Kinase inhibitor | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0428103-A2 | Prevention of glycoprotein enveloped virus infectivity by pyridyloxazole-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0428104-A2 | Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0428106-A1 | Novel pyridyloxazole 2-ones useful as proteinkinase C inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-05-22 | — | — | EP | disclosed |