Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.32 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ITK | Q08881 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9103156 | 1.00 | PDE3B (0.40) | PDE3BPDE3AECE1MUS81CDC7 | |
| SCHEMBL8846 | 0.80 | PDE3B (0.46) | PDE3BPDE3ACDC7CDK5CDK5R1 | |
| Fumaric Acid SCHEMBL8162 | 0.63 | GABRP (0.52) | ALDH1A1 | |
| Fumaric Acid SCHEMBL138088 | 0.63 | GABRP (0.52) | ALDH1A1 | |
| SCHEMBL7269315 | 0.60 | PDE3B (0.49) | PDE3BPDE3ACDC7CDK5MAPT | |
| SCHEMBL9360794 | 0.58 | ELANE (0.40) | ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10910752 | 0.57 | PDE3A (1.00) | PDE3BPDE3ACDK5CDK5R1ALDH1A1 | |
| SCHEMBL11234483 | 0.57 | PDE3B (0.62) | PDE3BPDE3ACDC7CDK5CDK5R1 | |
| SCHEMBL7278194 | 0.57 | NOTUM (0.45) | PDE3BPDE3ACDC7 | |
| SCHEMBL7415425 | 0.57 | ELANE (0.44) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9821039-B2 | Albumin fusion proteins | ALBUMEDIX A/S (DK) | 2017-11-21 | — | — | US | disclosed |
| US-20120141449-A1 | Albumin Fusion Proteins | DELTA BIOTECHNOLOGY LIMITED | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120141449-A1 | Albumin Fusion Proteins | ALB, FABP1, HDGF | SLC6A2 2730/4885PDE3B 4716/4885PDE3A 4769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.