Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.50 |
| ▸ | RARG | P13631 | 7/20 | 0.50 |
| ▸ | RXRA | P19793 | 4/20 | 0.50 |
| ▸ | RXRB | P28702 | 3/20 | 0.46 |
| ▸ | RXRG | P48443 | 3/20 | 0.46 |
| ▸ | RARA | P10276 | 7/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.42 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846008 | 0.85 | RXRA (0.46) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8845951 | 0.83 | RXRA (0.47) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8845359 | 0.83 | RXRA (0.42) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8845921 | 0.82 | PTGER1 (0.54) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8797209 | 0.81 | PTGER1 (0.55) | RXRARXRBRXRGPTGER1 | |
| SCHEMBL8846040 | 0.79 | PTGER1 (0.64) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8846090 | 0.78 | RARB (0.65) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL1013671 | 0.78 | RARG (0.59) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8846089 | 0.78 | RXRA (0.49) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8845334 | 0.77 | RXRB (0.46) | RARBRARGRXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | claimed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | claimed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | claimed |
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |