Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 5/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.46 |
| ▸ | CFD | P00746 | 3/20 | 0.43 |
| ▸ | F11 | P03951 | 3/20 | 0.43 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 4/20 | 0.43 |
| ▸ | RXRG | P48443 | 3/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845951 | 0.91 | RXRA (0.47) | RXRBCYP26A1RXRARXRGCYP26B1 | |
| SCHEMBL8845861 | 0.90 | RXRA (0.40) | RXRBRXRARXRGRARARARB | |
| SCHEMBL8846089 | 0.89 | RXRA (0.49) | RXRBRXRARXRGRARARARB | |
| SCHEMBL8845892 | 0.86 | PTGER1 (0.56) | RXRBCYP26A1CFDF11TPSB2 | |
| SCHEMBL8846454 | 0.84 | RARG (0.45) | RXRBCYP26A1RXRARXRGCYP26B1 | |
| SCHEMBL8846127 | 0.84 | CFD (0.53) | RXRBCYP26A1CFDF11TPSB2 | |
| SCHEMBL8845966 | 0.83 | CFD (0.46) | RXRBCFDF11TPSB2PLG | |
| SCHEMBL8846078 | 0.83 | MRGPRX4 (0.45) | RXRBCYP26A1RXRARXRGCYP26B1 | |
| SCHEMBL8845921 | 0.81 | PTGER1 (0.54) | RXRBCYP26A1RXRARXRGCYP26B1 | |
| SCHEMBL8846005 | 0.79 | RXRA (0.44) | RXRBCYP26A1CFDF11TPSB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | claimed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | claimed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | claimed |
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |