Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846106 | 0.93 | LTB4R (0.56) | LTB4RPTPN11PTGER1PTGER4PTGER3 | |
| SCHEMBL8846031 | 0.85 | PTGER1 (0.41) | PTGER1PTGER4PTGER3PTGER2FFAR1 | |
| SCHEMBL8845849 | 0.84 | PTPN11 (0.52) | LTB4RPTPN11PTGER1PTGER4PTGER3 | |
| SCHEMBL8845537 | 0.83 | PTPN11 (0.43) | LTB4RPTPN11PTGER1PTGER4PTGER3 | |
| SCHEMBL8846442 | 0.81 | PDE4A (0.45) | PTGER1PTGER4PTGER3PTGER2FFAR1 | |
| SCHEMBL8846113 | 0.80 | PTPN11 (0.61) | PTPN11PTGER1MRGPRX4 | |
| SCHEMBL8845814 | 0.79 | PTGER1 (0.43) | PTGER1PTGER4PTGER3PTGER2FFAR1 | |
| SCHEMBL8845944 | 0.79 | PTPN11 (0.63) | LTB4RPTPN11PTGER1MRGPRX4 | |
| SCHEMBL8846020 | 0.76 | HPGD (0.42) | PTPN11CNR2MRGPRX4 | |
| SCHEMBL8846136 | 0.74 | PTPN11 (0.53) | PTPN11CNR2MRGPRX4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |