Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 4/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | CFD | P00746 | 2/20 | 0.44 |
| ▸ | F11 | P03951 | 2/20 | 0.44 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845537 | 0.92 | PTPN11 (0.43) | PTPN11MRGPRX4PTPN1PTPN6LTB4R | |
| SCHEMBL8846106 | 0.91 | LTB4R (0.56) | PTPN11MRGPRX4LTB4RPTGER1PPARA | |
| SCHEMBL8845847 | 0.89 | PTPN11 (0.53) | PTPN11PTGER1 | |
| SCHEMBL8846113 | 0.88 | PTPN11 (0.61) | PTPN11MRGPRX4PTPN1PTPN6PTGER1 | |
| SCHEMBL8845944 | 0.87 | PTPN11 (0.63) | PTPN11MRGPRX4PTPN1PTPN6LTB4R | |
| SCHEMBL8846006 | 0.84 | LTB4R (0.48) | PTPN11MRGPRX4LTB4RPTGER1PTGER4 | |
| SCHEMBL8845974 | 0.81 | PLA2G4B (0.46) | PTPN11PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8846136 | 0.81 | PTPN11 (0.53) | PTPN11MRGPRX4PTPN1PTPN6 | |
| SCHEMBL8846484 | 0.79 | PDE4A (0.52) | MRGPRX4CFDF11TPSB2PLG | |
| SCHEMBL8845966 | 0.78 | CFD (0.46) | MRGPRX4CFDF11TPSB2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | claimed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | claimed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | claimed |
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |