Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 5/20 | 0.45 |
| ▸ | FAAH | O00519 | 4/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RARA | P10276 | 2/20 | 0.42 |
| ▸ | RARB | P10826 | 2/20 | 0.42 |
| ▸ | RARG | P13631 | 2/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | GOT1 | P17174 | 1/20 | 0.42 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846138 | 0.93 | MRGPRX4 (0.47) | S1PR1CNR2FAAHMEN1KMT2A | |
| SCHEMBL8845999 | 0.86 | KMT2A (0.43) | S1PR1CNR2FAAHCNR1MEN1 | |
| SCHEMBL8846139 | 0.83 | S1PR1 (0.45) | S1PR1CNR2FAAHCNR1MEN1 | |
| SCHEMBL8846063 | 0.82 | MRGPRX4 (0.45) | S1PR1MEN1KMT2AMRGPRX4LMNA | |
| SCHEMBL8845880 | 0.77 | NPC1 (0.41) | S1PR1MEN1KMT2AMRGPRX4SMN1; SMN2 | |
| SCHEMBL8845951 | 0.77 | RXRA (0.47) | MRGPRX4RARARARBRARGRXRA | |
| SCHEMBL8394152 | 0.76 | PTGER4 (0.46) | S1PR1CNR2FAAHMEN1KMT2A | |
| SCHEMBL8394232 | 0.76 | KDM4E (0.52) | CNR2FAAHMEN1KMT2ALMNA | |
| SCHEMBL9160266 | 0.74 | FABP4 (0.47) | CNR2FAAHMEN1KMT2ALMNA | |
| SCHEMBL8459851 | 0.74 | RARB (0.50) | S1PR1CNR2FAAHMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |