Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847143 | 0.89 | CA2 (0.44) | GRIK1GRIK2CHRM1AKR1A1CHRM3 | |
| SCHEMBL8847118 | 0.87 | CHRM1 (0.47) | GRIK1GRIK2CHRM1AKR1A1CHRM3 | |
| SCHEMBL8847113 | 0.83 | GRIK1 (0.56) | GRIK1GRIK2CHRM1AKR1A1CHRM3 | |
| SCHEMBL8847127 | 0.82 | GRIK1 (0.50) | GRIK1GRIK2CHRM1AKR1A1CHRM3 | |
| SCHEMBL5053789 | 0.80 | CHRM1 (0.62) | GRIK1GRIK2CHRM1AKR1A1CHRM3 | |
| SCHEMBL7557794 | 0.80 | CHRM1 (0.62) | GRIK1GRIK2CHRM1AKR1A1CHRM3 | |
| SCHEMBL17150576 | 0.80 | CA2 (0.58) | GRIK1GRIK2CHRM1AKR1A1CHRM3 | |
| SCHEMBL7191105 | 0.80 | CA2 (0.58) | GRIK1GRIK2CHRM1AKR1A1CHRM3 | |
| SCHEMBL3104177 | 0.80 | — | — | |
| SCHEMBL8847119 | 0.79 | GRIK1 (0.47) | GRIK1GRIK2CHRM1AKR1A1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778820-A1 | NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1997-06-18 | — | — | EP | claimed |
| WO-1996006821-A1 | NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1996-03-07 | — | — | WO | claimed |