Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | GRIK1 | P39086 | 7/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 7/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557794 | 1.00 | CHRM1 (0.62) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL7551496 | 0.88 | CA2 (0.61) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL8847118 | 0.87 | CHRM1 (0.47) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL19306557 | 0.86 | CA2 (0.53) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL7552288 | 0.86 | CA2 (0.53) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL3839934 | 0.86 | CA2 (0.53) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL7552503 | 0.84 | GRIK1 (0.54) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL3864872 | 0.84 | GRIK1 (0.54) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL3785993 | 0.84 | GRIK1 (0.54) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL3857718 | 0.84 | GRIK1 (0.54) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008131940-A2 | COMBINED IMMUNOLOGICAL AGENT AND SENSITIZING AGENT FOR THE TREATMENT OF CANCER | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2008-11-06 | — | — | WO | claimed |
| US-20080267977-A1 | Combined immunological agent and sensitizing agent for the treatment of cancer | FRIEDRICH-ALEXANDER UNIVERSITY OF ERLANGEN-NUREMBERG (DE) | 2008-10-30 | — | — | US | claimed |
| US-20050038113-A1 | Valproic acid and derivatives for the combinatorial therapeutic treatment of human cancers and for the treatment of tumor metastasis and minimal residual disease | G2M CANCER DRUGS AG (DE) | 2005-02-17 | — | — | US | claimed |
| US-RE37670-E1 | Antiproliferative and neurotrophic molecules | AMERICAN BIOGENETICS INC. | 2002-04-23 | — | — | US | claimed |
| US-20020013367-A1 | Antiproliferative and neurotrophic molecules | NAU HEINZ (DE) | 2002-01-31 | — | — | US | claimed |
| US-6300373-B1 | CONTACTING NEURONAL CELLS WITH A NEUROTROPHIC AMOUNT CARBOXYLIC ACID DERIVATIVE FOR PROVIDING NEUROTROPHIC ACTIVITY | AMERICAN BIOGENETIC SCIENCES, INC. | 2001-10-09 | — | — | US | claimed |
| EP-0778820-B1 | NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS | AMERICAN BIOGENETIC SCIENCES (US) | 2001-05-02 | — | — | EP | claimed |
| US-5672746-A | UNSATURATED ALKYL CARBOXYLIC ACIDS(AND THEIR SALTS) FOR TREATMENT OR PREVENTION OF NERVOUS SYSTEM DISORDERS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1997-09-30 | — | — | US | claimed |
| EP-0778820-A1 | NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1997-06-18 | — | — | EP | claimed |
| WO-1996006821-A1 | NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1996-03-07 | — | — | WO | claimed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-11260130-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV | Frequency Therapeutics, Inc. (US) | 2022-03-01 | — | — | US | disclosed |
| US-11033546-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: I | Frequency Therapeutics, Inc. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20190201398-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING A GSK3 INHIBITOR: I | Frequency Therapeutics, Inc. | 2019-07-04 | — | — | US | disclosed |
| US-20190093079-A1 | METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK-3-ALPHA INHIBITORS | Frequency Therapeutics, Inc. | 2019-03-28 | — | — | US | disclosed |
| US-5672746-A | UNSATURATED ALKYL CARBOXYLIC ACIDS(AND THEIR SALTS) FOR TREATMENT OR PREVENTION OF NERVOUS SYSTEM DISORDERS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0778820-A1 | NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1997-06-18 | — | — | EP | disclosed |
| EP-0778820-A1 | NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1997-06-18 | — | — | EP | disclosed |
| WO-1996006821-A1 | NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1996-03-07 | — | — | WO | disclosed |
| WO-1996006821-A1 | NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1996-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038113-A1 | Valproic acid and derivatives for the combinatorial therapeutic treatment of human cancers and for the treatment of tumor metastasis and minimal residual disease | HDAC2, HDAC5, HDAC1 | CHRM1 3444/4885AKR1A1 1278/4885CHRM3 3376/4885 |
| US-20190093079-A1 | METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK-3-ALPHA INHIBITORS | GSK3A, GSK3B, NOTCH3 | CHRM1 4762/4885AKR1A1 3489/4885CHRM3 4495/4885 |
| US-20020013367-A1 | Antiproliferative and neurotrophic molecules | BDNF, NGF, NTRK2 | CHRM1 4273/4885AKR1A1 2994/4885CHRM3 4111/4885 |
| US-11033546-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: I | GSK3B, GSK3A, GSKIP | CHRM1 4845/4885AKR1A1 2497/4885CHRM3 4772/4885 |
| US-20190201398-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING A GSK3 INHIBITOR: I | GSK3B, GSK3A, GSKIP | CHRM1 4845/4885AKR1A1 2497/4885CHRM3 4772/4885 |
| US-11260130-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV | GSK3B, GSK3A, GSKIP | CHRM1 4854/4885AKR1A1 2364/4885CHRM3 4768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.