Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884711 | 0.98 | TSHR (0.62) | TSHRRECQLPOLBSMN1; SMN2GLA | |
| SCHEMBL884837 | 0.95 | TSHR (0.58) | TSHRRECQLPOLBSMN1; SMN2GLA | |
| SCHEMBL3769090 | 0.78 | TSHR (0.56) | TSHRRECQLPOLBSMN1; SMN2GLA | |
| SCHEMBL30498780 | 0.78 | TSHR (0.97) | TSHRRECQLPOLBSMN1; SMN2GLA | |
| SCHEMBL22692601 | 0.78 | TSHR (0.97) | TSHRRECQLPOLBSMN1; SMN2GLA | |
| SCHEMBL7822892 | 0.78 | L3MBTL1 (0.73) | TSHRRECQLPOLBSMN1; SMN2GLA | |
| SCHEMBL3760644 | 0.77 | TSHR (0.57) | TSHRRECQLPOLBSMN1; SMN2GLA | |
| SCHEMBL10720608 | 0.76 | TSHR (0.69) | TSHRRECQLPOLBSMN1; SMN2GLA | |
| SCHEMBL1642860 | 0.76 | HPGD (0.55) | TSHRRECQLSMN1; SMN2GLAHTT | |
| SCHEMBL4057568 | 0.75 | MAPT (0.68) | TSHRRECQLPOLBSMN1; SMN2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |