⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4611420 | 0.79 | ACACB (0.36) | — | |
| SCHEMBL7436621 | 0.78 | MMP8 (0.34) | — | |
| SCHEMBL28292468 | 0.74 | MMP8 (0.37) | — | |
| SCHEMBL8846435 | 0.73 | TSHR (0.32) | — | |
| SCHEMBL4138413 | 0.72 | MMP8 (0.47) | — | |
| SCHEMBL4393248 | 0.72 | — | — | |
| Bicarbonate SCHEMBL9087678 | 0.71 | CA2 (0.33) | — | |
| SCHEMBL24593985 | 0.71 | MMP8 (0.32) | — | |
| SCHEMBL24183125 | 0.70 | ACACB (0.33) | — | |
| SCHEMBL276729 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |