SCHEMBL8848705

SCHEMBL8848705

CNc1ccc(C(CC2CO2)(CC2CO2)c2ccc(NC)cc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.39
TSHR P16473 3/20 0.37
TP53 P04637 2/20 0.37
MAPT P10636 2/20 0.37
HPGD P15428 2/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
CYP1A2 P05177 1/20 0.37
ALDH1A1 P00352 1/20 0.37
PPARG P37231 1/20 0.37
HIF1A Q16665 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1203775 0.76 MAPT (0.36) KIF11TSHRTP53MAPTHPGD
SCHEMBL25359833 0.75 MEN1 (0.45) TSHRTP53MAPTHPGDMEN1
SCHEMBL8752427 0.70 GRM5 (0.43) TSHRTP53HPGDMEN1KMT2A
SCHEMBL13948472 0.68 ALDH1A1 (0.60) TSHRTP53MAPTHPGDMEN1
SCHEMBL8848871 0.68 CHRM2 (0.34) TSHR
SCHEMBL15169281 0.68 ALDH1A1 (0.60) TSHRTP53MAPTHPGDMEN1
SCHEMBL9861061 0.67 MEN1 (0.38) TSHRMEN1KMT2A
SCHEMBL10788154 0.65 PSMD14 (0.36) TSHRMEN1KMT2AALDH1A1
SCHEMBL13349635 0.65 TSHR (0.50) KIF11TSHRTP53HPGDALDH1A1
SCHEMBL16641019 0.64 HPGD (0.51) TSHRTP53MAPTHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0785241-A2 Effect powder paint, its preparation and application HÜLS AKTIENGESELLSCHAFT (DE) 1997-07-23 EP claimed
EP-0785241-A2 Effect powder paint, its preparation and application HÜLS AKTIENGESELLSCHAFT (DE) 1997-07-23 EP disclosed
EP-0253101-B1 POWDER COATING, ITS PREPARATION AND APPLICATION HÜLS AKTIENGESELLSCHAFT (DE) 1993-03-03 EP disclosed
EP-0253115-B1 POWDER COATING, ITS PREPARATION AND APPLICATION HÜLS AKTIENGESELLSCHAFT (DE) 1992-10-14 EP disclosed
EP-0201340-B1 TONER COMPOSITION AND METHOD FOR PREPARING THE SAME Kao Corporation (JP) 1992-04-01 EP disclosed
US-5036144-A Powdered lacquer of epoxy resin of diamine-benzene polycarboxylic acid salt HUELS AKTIENGESELLSCHAFT (DE) 1991-07-30 US disclosed
US-4788076-A EPOXIDE, AMINE SALT HULS AKTIENGESELLSCHAFT (DE) 1988-11-29 US disclosed
US-4749638-A CARBON BLACK, DISPERSANT, POLYMERIC BINDER OIL PHASE EMULSION POLYMERIZATION KAO CORPORATION (JP) 1988-06-07 US disclosed
US-4695613-A EPOXY RESIN, CYCLIC AMIDINE NEUTRALIZED OLIGOESTER HUELS AKTIENGESELLSCHAFT (DE) 1987-09-22 US disclosed
EP-0175874-B1 CARBOXYL GROUP CONTAINING CURING AGENTS HÜLS AKTIENGESELLSCHAFT (DE) 1987-09-09 EP disclosed
EP-0201340-A2 Toner composition and method for preparing the same Kao Corporation (JP) 1986-11-12 EP disclosed
EP-0198226-A2 Curing agent for an epoxy resin-based powdery coating HÜLS AKTIENGESELLSCHAFT (DE) 1986-10-22 EP disclosed
EP-0175874-A1 Carboxyl group containing curing agents HÜLS AKTIENGESELLSCHAFT (DE) 1986-04-02 EP disclosed
EP-0000418-A1 Process for glueing materials CHEMISCHE WERKE HÜLS AG (DE) 1979-01-24 EP disclosed
US-4127562-A HARDENER, VARNISH ADDITIVES, 1,2-EPOXY COMPOUNDS VEBA-CHEMIE AKTIENGESELLSCHAFT (DE) 1978-11-28 US disclosed
US-4064110-A FROM 5-ALKOXYMETHYL-1,3,4-DIOXAZOL-2-ONES, ALKALI METAL CARBOXYLATE CATALYST BAYER AKTIENGESELLSCHAFT (DT) 1977-12-20 US disclosed
US-4014954-A Method for preparing moldings and coatings VEBA-CHEMIE AG (DT) 1977-03-29 US disclosed