Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8849336 | 0.99 | TSHR (0.47) | SMN1; SMN2NPC1RAB9ATSHRHSD17B10 | |
| SCHEMBL8848700 | 0.92 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9ATSHRHSD17B10 | |
| SCHEMBL8849188 | 0.89 | MAPK1 (0.52) | SMN1; SMN2NPC1RAB9ATSHRL3MBTL1 | |
| SCHEMBL8848714 | 0.87 | HSD17B10 (0.51) | SMN1; SMN2NPC1RAB9ATSHRHSD17B10 | |
| SCHEMBL8848642 | 0.86 | HSD17B10 (0.52) | SMN1; SMN2NPC1RAB9ATSHRHSD17B10 | |
| SCHEMBL8848658 | 0.85 | TP53 (0.45) | SMN1; SMN2RAB9ATSHRHSD17B10LMNA | |
| SCHEMBL8848912 | 0.84 | LTA4H (0.54) | SMN1; SMN2NPC1RAB9ATSHRHSD17B10 | |
| SCHEMBL8848405 | 0.82 | NPC1 (0.64) | SMN1; SMN2NPC1RAB9ATSHRHSD17B10 | |
| SCHEMBL8848828 | 0.82 | LTA4H (0.47) | SMN1; SMN2NPC1RAB9ATSHRHSD17B10 | |
| SCHEMBL8848588 | 0.81 | LTA4H (0.48) | SMN1; SMN2NPC1RAB9ATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602161-A | ELASTASE INHIBITORS; PREVENTING AND TREATING EMPHYSEMA, ENDOTOXIN-INDUCED LUNG DISORDERS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-11 | — | — | US | disclosed |
| EP-0676396-A1 | Tetrazolylphenyl pivalate derivatives and medicinal composition containing the same as effective component | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1995-10-11 | — | — | EP | disclosed |