Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.36 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5279859 | 1.00 | CA12 (0.41) | CA12CA1CA2CA7CA9 | |
| Bromide SCHEMBL8848766 | 0.87 | ALDH1A1 (0.44) | KMT2AALDH1A1MEN1 | |
| Bromide SCHEMBL8848768 | 0.87 | ALDH1A1 (0.44) | KMT2AALDH1A1MEN1 | |
| Bromide SCHEMBL19469275 | 0.86 | CHRM2 (0.53) | KMT2AKDM4EALDH1A1CTDSP1MEN1 | |
| Bromide SCHEMBL19469280 | 0.86 | CHRM2 (0.53) | KMT2AKDM4EALDH1A1CTDSP1MEN1 | |
| SCHEMBL29930859 | 0.85 | CHRM2 (0.51) | KMT2AKDM4EALDH1A1CTDSP1MEN1 | |
| SCHEMBL19506334 | 0.85 | CHRM2 (0.51) | KMT2AKDM4EALDH1A1CTDSP1MEN1 | |
| Bromide SCHEMBL5391070 | 0.85 | KMT2A (0.43) | CA12CA1CA2CA7CA9 | |
| Bromide SCHEMBL9243928 | 0.79 | ALDH1A1 (0.47) | KMT2AKDM4EALDH1A1CYP3A4MEN1 | |
| SCHEMBL8971275 | 0.77 | ALDH1A1 (0.45) | KMT2AKDM4EALDH1A1MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555070-B1 | Photocurable compositions | SERICOL LTD (GB) | 1997-04-16 | — | — | EP | disclosed |
| US-5332651-A | Screen printing | SERICOL LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0555070-A1 | Photocurable compositions | SERICOL LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |