SCHEMBL8849490

SCHEMBL8849490

COCOCCCc1ccc(C(C)(C)C)cc1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.49
SIGMAR1 Q99720 5/20 0.44
MITF O75030 1/20 0.41
LMNA P02545 1/20 0.40
ESRRG P62508 1/20 0.39
NR1H4 Q96RI1 1/20 0.38
GRIA4 P48058 1/20 0.36
ACHE P22303 1/20 0.36
APP P05067 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
SLC13A5 Q86YT5 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16770391 0.85 KCNH2 (0.55) KCNH2SIGMAR1MITFLMNAESRRG
SCHEMBL6370599 0.81 KCNH2 (0.50) KCNH2SIGMAR1MITFLMNAESRRG
SCHEMBL30151187 0.80 KCNH2 (0.58) KCNH2SIGMAR1MITFLMNAESRRG
SCHEMBL8724971 0.80 KCNH2 (0.58) KCNH2SIGMAR1MITFLMNAESRRG
SCHEMBL24811923 0.79 KCNH2 (0.53) KCNH2SIGMAR1MITFLMNAESRRG
SCHEMBL1890232 0.77 KCNH2 (0.48) KCNH2SIGMAR1MITFLMNAESRRG
SCHEMBL31573982 0.77 KCNH2 (0.67) KCNH2SIGMAR1MITFLMNAESRRG
SCHEMBL16245651 0.76 CXCR1 (0.36) KCNH2SIGMAR1LMNATDP1L3MBTL1
SCHEMBL23015030 0.76 KCNH2 (0.53) KCNH2SIGMAR1MITFLMNAESRRG
SCHEMBL25590542 0.76 KCNH2 (0.53) KCNH2SIGMAR1MITFLMNAESRRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0652861-B1 NOVEL AROMATIC COMPOUNDS AND THEIR USE IN PERFUME PRODUCTS FIRMENICH & CIE (CH) 1997-09-03 EP disclosed
US-5527769-A AROMATIC ALDEHYDES OR ACETALS IMPART FLORAL FRAGRANCES FIRMENICH SA (CH) 1996-06-18 US disclosed