Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 4/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ESRRB | O95718 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16770391 | 0.88 | KCNH2 (0.55) | KCNH2ESRRGMITFESRRBSIGMAR1 | |
| SCHEMBL13904118 | 0.87 | ESRRG (0.39) | KCNH2ESRRGESRRBMEN1KMT2A | |
| SCHEMBL793588 | 0.84 | KCNH2 (0.50) | KCNH2ESRRGMITFESRRBSIGMAR1 | |
| SCHEMBL1338713 | 0.83 | NR3C1 (0.44) | SIGMAR1L3MBTL1 | |
| SCHEMBL7456580 | 0.81 | KCNH2 (0.59) | KCNH2ESRRGESRRBSIGMAR1GRIA4 | |
| SCHEMBL14274242 | 0.81 | TAAR1 (0.55) | MEN1KMT2ADAO | |
| SCHEMBL1890230 | 0.81 | KCNH2 (0.47) | KCNH2ESRRGMITFESRRBSIGMAR1 | |
| SCHEMBL25728101 | 0.80 | CYP1A2 (0.41) | KCNH2ESRRGRAB9ANPC1MAPT | |
| SCHEMBL29151515 | 0.79 | ALDH1A1 (0.62) | RAB9AMEN1KMT2ANPC1APP | |
| SCHEMBL28725536 | 0.77 | ESR1 (0.34) | KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11673864-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-06-13 | — | — | US | disclosed |
| US-11673864-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-06-13 | — | — | US | disclosed |
| US-20210047271-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC | 2021-02-18 | — | — | US | disclosed |
| US-10738009-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-08-11 | — | — | US | disclosed |
| US-10640520-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2020-05-05 | — | — | US | disclosed |
| US-20190248745-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2019-08-15 | — | — | US | disclosed |
| US-10294246-B2 | Substituted boronic acids and boronate esters as immunoproteasome inhibitors | MERCK PATENT GMBH (DE) | 2019-05-21 | — | — | US | disclosed |
| US-10253049-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2019-04-09 | — | — | US | disclosed |
| US-20180179231-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-06-28 | — | — | US | disclosed |
| US-20180105538-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-04-19 | — | — | US | disclosed |
| US-7947342-B2 | Polarizer protective film, manufacturing method thereof, polarizing plate and liquid crystal display | KONICA MINOLTA OPTO, INC. (JP) | 2011-05-24 | — | — | US | disclosed |
| US-7854864-B2 | Method for manufacturing an optical film having a convexoconcave structure | KONICA MINOLTA OPTO, INC. (JP) | 2010-12-21 | — | — | US | disclosed |
| US-20100236713-A1 | FILM FOR DISPLAY, POLARIZING PLATE AND MANUFACTURING METHOD THEREOF, AND LIQUID CRYSTAL DISPLAY | KONICA MINOLTA OPTO, INC. (JP) | 2010-09-23 | — | — | US | disclosed |
| EP-2012150-A1 | POLARIZING PLATE PROTECTION FILM, METHOD FOR PRODUCING THE SAME, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY | Konica Minolta Opto, Inc. (JP) | 2009-01-07 | — | — | EP | disclosed |
| EP-2006716-A1 | FILM FOR DISPLAY, POLARIZING PLATE AND METHOD FOR PRODUCING THE SAME, AND LIQUID CRYSTAL DISPLAY | Konica Minolta Opto, Inc. (JP) | 2008-12-24 | — | — | EP | disclosed |
| US-20080043176-A1 | Method of Manufacturing a Polarizing Plate Protective Film, Polarizing Plate Protective Film, Polarizing Plate, and Liquid Crystal Display Device | KONICA MINOLTA OPTO, INC. (JP) | 2008-02-21 | — | — | US | disclosed |
| US-20080013173-A1 | METHOD OF MANUFACTURING A POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE | KONICA MINOLTA OPTO, INC. (JP) | 2008-01-17 | — | — | US | disclosed |
| US-20070252293-A1 | METHOD FOR MANUFACTURING AN OPTICAL FILM HAVING A CONVEXOCONCAVE STRUCTURE, OPTICAL FILM, WIRE GRID POLARIZER AND RETARDATION FILM | KONICA MINOLTA OPTO, INC. (JP) | 2007-11-01 | — | — | US | disclosed |
| US-20070254115-A1 | Polarizer protective film, manufacturing method thereof, polarizing plate and liquid crystal display | KONICA MINOLTA OPTO, INC. (JP) | 2007-11-01 | — | — | US | disclosed |
| US-20070227652-A1 | FILM FOR DISPLAY, POLARIZING PLATE AND MANUFACTURING METHOD THEREOF, AND LIQUID CRYSTAL DISPLAY | KONICA MINOLTA OPTO, INC. (JP) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179231-A1 | BORONIC ACID DERIVATIVES | BCL9, BCL9L, BCL6 | KCNH2 1887/4885ESRRG 1268/4885MITF 1027/4885 |
| US-20180105538-A1 | BORONIC ACID DERIVATIVES | BCL9, BCL9L, BCL6 | KCNH2 1887/4885ESRRG 1268/4885MITF 1027/4885 |
| US-10738009-B2 | Pyridone amides as modulators of sodium channels | SCN5A, SCN1A, KCNJ2 | KCNH2 4/4885ESRRG 4327/4885MITF 4173/4885 |
| US-10640520-B2 | Boronic acid derivatives | BCL9, BCL9L, BCL6 | KCNH2 1887/4885ESRRG 1268/4885MITF 1027/4885 |
| US-10294246-B2 | Substituted boronic acids and boronate esters as immunoproteasome inhibitors | PSMB7, PSMA7, PSMB11 | KCNH2 3554/4885ESRRG 2232/4885MITF 1946/4885 |
| US-20210047271-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | KCNH2 4/4885ESRRG 4327/4885MITF 4173/4885 |
| US-10253049-B2 | Boronic acid derivatives | BCL9, BCL9L, BCL6 | KCNH2 1887/4885ESRRG 1268/4885MITF 1027/4885 |
| US-11673864-B2 | Pyridone amides as modulators of sodium channels | SCN5A, SCN1A, KCNJ2 | KCNH2 4/4885ESRRG 4327/4885MITF 4173/4885 |
| US-20190248745-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | KCNH2 4/4885ESRRG 4327/4885MITF 4173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.