Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.61 |
| ▸ | INSR | P06213 | 9/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885288 | 0.93 | MET (0.70) | METINSR | |
| SCHEMBL885271 | 0.87 | MET (0.51) | METINSRALK | |
| SCHEMBL885368 | 0.85 | MET (0.56) | METINSRALK | |
| SCHEMBL2911668 | 0.84 | MET (0.49) | METINSRALK | |
| SCHEMBL2060977 | 0.80 | MET (0.63) | METINSRALK | |
| SCHEMBL16965964 | 0.80 | MET (0.43) | METINSRALK | |
| SCHEMBL886473 | 0.79 | MET (0.64) | METINSRALK | |
| SCHEMBL885888 | 0.78 | INSR (0.81) | METINSRALK | |
| SCHEMBL885031 | 0.78 | MET (0.60) | METINSRALK | |
| SCHEMBL886232 | 0.78 | MET (0.72) | METINSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | claimed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |