Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.59 |
| ▸ | BCHE | P06276 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | ICMT | O60725 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8642987 | 1.00 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL16727723 | 0.93 | HDAC1 (0.63) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL10150374 | 0.93 | ALDH1A1 (0.57) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL11273441 | 0.90 | ALDH1A1 (0.57) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL9824509 | 0.86 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL17763505 | 0.85 | CARM1 (0.50) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL8544592 | 0.85 | BCHE (0.58) | BCHEACHEALDH1A1APPMAOB | |
| SCHEMBL24685749 | 0.84 | HDAC3 (0.50) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| Ethylene SCHEMBL9824504 | 0.83 | HDAC3 (0.56) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL25181480 | 0.83 | HDAC1 (0.67) | HDAC3HDAC1HDAC2HDAC8NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654484-A | Polyamine derivatives as antineoplastic agents | MERRELL PHARMACEUTICALS INC. (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0399519-B1 | Potentiating cell-mediated immunity utilizing polyamine derivatives | MERRELL PHARMA INC (US) | 1996-08-07 | — | — | EP | disclosed |
| EP-0662829-A1 | POLYAMINE DERIVATIVES AS ANTI-CYTOMEGALOVIRAL AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994007480-A1 | POLYAMINE DERIVATIVES AS ANTI-CYTOMEGALOVIRAL AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5109024-A | Polyamine derivatives as antineoplastic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0399519-A2 | Potentiating cell-mediated immunity utilizing polyamine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1990-11-28 | — | — | EP | disclosed |