Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851118 | 0.90 | PDE10A (0.47) | PDE10AL3MBTL1ALDH1A1KDM4EHTT | |
| SCHEMBL8851202 | 0.89 | PDE10A (0.45) | PDE10AALDH1A1CSF1RSMN1; SMN2KDM4E | |
| SCHEMBL8851222 | 0.88 | POLB (0.46) | PDE10AALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL8851433 | 0.86 | PDE10A (0.48) | PDE10AALDH1A1KDM4EHDAC1KMT2A | |
| SCHEMBL8852111 | 0.83 | PDE10A (0.44) | PDE10AMAPTL3MBTL1ALDH1A1PIK3CA | |
| SCHEMBL9234751 | 0.81 | SMN1; SMN2 (0.46) | PDE10AALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL8851490 | 0.80 | SMN1; SMN2 (0.42) | PDE10AALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL8851946 | 0.80 | RAB9A (0.50) | PDE10AMAPTL3MBTL1PIK3CAKDM4E | |
| SCHEMBL10663061 | 0.80 | PDE10A (0.49) | PDE10AMAPTL3MBTL1ALDH1A1PIK3CA | |
| SCHEMBL8851390 | 0.78 | PIK3CB (0.48) | ALDH1A1PIK3CASMN1; SMN2KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |