Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664494 | 0.88 | LMNA (0.45) | SMN1; SMN2LMNAKMT2AMEN1KDM4E | |
| SCHEMBL8851087 | 0.84 | MEN1 (0.46) | SMN1; SMN2LMNAKMT2AMEN1ALOX15 | |
| SCHEMBL8851150 | 0.81 | PDE10A (0.48) | SMN1; SMN2LMNAKMT2APDE10AKDM4E | |
| SCHEMBL10657517 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAKMT2AMEN1ALOX15 | |
| SCHEMBL8851118 | 0.78 | PDE10A (0.47) | KMT2APDE10AKDM4EALDH1A1 | |
| SCHEMBL8851490 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAKMT2AMEN1GAK | |
| SCHEMBL8851202 | 0.78 | PDE10A (0.45) | SMN1; SMN2LMNAKMT2APDE10AKDM4E | |
| SCHEMBL8851222 | 0.77 | POLB (0.46) | SMN1; SMN2LMNAKMT2APDE4BPDE4A | |
| SCHEMBL8851433 | 0.76 | PDE10A (0.48) | KMT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL10658148 | 0.74 | LMNA (0.42) | SMN1; SMN2LMNAKMT2AMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |