Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 3/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851887 | 0.95 | PDE10A (0.40) | PDE10AMAPTHTTLMNANPSR1 | |
| SCHEMBL8851802 | 0.91 | MAPT (0.40) | PDE10AMAPTHTTLMNANPSR1 | |
| SCHEMBL8851409 | 0.90 | PDE10A (0.42) | PDE10AMAPTHTTLMNANPSR1 | |
| SCHEMBL8851316 | 0.90 | PIK3CD (0.36) | PDE10AMTOR | |
| SCHEMBL8851107 | 0.89 | PDE10A (0.41) | PDE10AMAPTHTTLMNANPSR1 | |
| SCHEMBL8852053 | 0.89 | EHMT2 (0.43) | PDE10AMAPTHTTLMNANPSR1 | |
| SCHEMBL8851821 | 0.88 | PIK3CD (0.35) | PDE10AMTOR | |
| SCHEMBL9233809 | 0.88 | EHMT2 (0.44) | PDE10AMAPTHTTLMNANPSR1 | |
| SCHEMBL8851225 | 0.87 | PDE10A (0.44) | PDE10AMAPTHTTLMNANPSR1 | |
| SCHEMBL8851209 | 0.86 | LMNA (0.41) | MAPTHTTLMNANPSR1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | claimed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | claimed |
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |