Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851143 | 0.87 | ALDH1A1 (0.36) | METAP1KDM4EPOLBCA12CA2 | |
| SCHEMBL8851413 | 0.83 | LMNA (0.41) | LMNAKDM4E | |
| SCHEMBL8851741 | 0.82 | METAP1 (0.33) | METAP1KDM4EPOLB | |
| SCHEMBL13568246 | 0.82 | KDM4E (0.46) | KDM4EPOLBALDH1A1L3MBTL1 | |
| SCHEMBL8851281 | 0.81 | LMNA (0.47) | LMNACYP2C19 | |
| SCHEMBL556147 | 0.81 | KDM4E (0.32) | LMNAMETAP1KDM4EPOLBALDH1A1 | |
| SCHEMBL8851191 | 0.79 | EPHX1 (0.42) | LMNAMETAP1KDM4EPOLBCA12 | |
| SCHEMBL9146801 | 0.77 | METAP1 (0.37) | METAP1KDM4EPOLBALDH1A1L3MBTL1 | |
| SCHEMBL8851320 | 0.76 | GAA (0.42) | METAP1KDM4EPOLBALDH1A1L3MBTL1 | |
| SCHEMBL9141301 | 0.76 | METAP1 (0.35) | METAP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |