Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28895715 | 1.00 | CA2 (0.54) | CA2MAPK1ACE2CA1MAPT | |
| Bicarbonate SCHEMBL216624 | 1.00 | CA2 (0.54) | CA2MAPK1ACE2CA1MAPT | |
| Bicarbonate SCHEMBL28584877 | 1.00 | CA2 (0.54) | CA2MAPK1ACE2CA1MAPT | |
| Bicarbonate SCHEMBL9230330 | 0.98 | CA2 (0.52) | CA2MAPK1ACE2CA1MAPT | |
| Bicarbonate SCHEMBL973799 | 0.98 | CA2 (0.52) | CA2MAPK1ACE2CA1MAPT | |
| Acetic Acid SCHEMBL4207526 | 0.93 | CA2 (0.52) | CA2MAPK1ACE2CA1MAPT | |
| Propionic Acid SCHEMBL28527697 | 0.91 | CA2 (0.50) | CA2MAPK1ACE2CA1MAPT | |
| Acetic Acid SCHEMBL9623423 | 0.91 | ACE2 (0.53) | CA2MAPK1ACE2CA1MAPT | |
| Acetic Acid SCHEMBL7095795 | 0.91 | CA2 (0.50) | CA2MAPK1ACE2CA1MAPT | |
| Bicarbonate SCHEMBL18274643 | 0.91 | ACE2 (0.64) | CA2ACE2CA1MAPTGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325423-B1 | NOVEL SHRINKAGE REDUCER FOR MINERAL BINDING AGENTS | EVONIK OPERATIONS GMBH (DE) | 2020-02-19 | — | — | EP | claimed |
| EP-3325423-A1 | NOVEL SHRINKAGE-REDUCING AGENTS FOR MINERAL BINDERS | Evonik Degussa GmbH (DE) | 2018-05-30 | — | — | EP | claimed |
| EP-1668053-B1 | AUXILIARY LIQUID RHEOLOGICAL MEDIUM, METHOD FOR THE PRODUCTION AND USE THEREOF | BASF COATINGS AG (DE) | 2007-06-13 | — | — | EP | claimed |
| EP-1668053-A1 | AUXILIARY LIQUID RHEOLOGICAL MEDIUM, METHOD FOR THE PRODUCTION AND USE THEREOF | BASF Coatings AG (DE) | 2006-06-14 | — | — | EP | claimed |
| WO-2005033166-A1 | AUXILIARY LIQUID RHEOLOGICAL MEDIUM, METHOD FOR THE PRODUCTION AND USE THEREOF | BASF COATINGS AG (DE) | 2005-04-14 | — | — | WO | claimed |
| EP-0677548-A1 | Rubber composition | Semperit Reifen Aktiengesellschaft (AT) | 1995-10-18 | — | — | EP | claimed |
| EP-3228649-B1 | TREATMENT OF ALKOXYLATION PRODUCTS OBTAINED BY ALKALINE CATALYSIS | EVONIK OPERATIONS GMBH (DE) | 2020-07-15 | — | — | EP | disclosed |
| EP-3325423-B1 | NOVEL SHRINKAGE REDUCER FOR MINERAL BINDING AGENTS | EVONIK OPERATIONS GMBH (DE) | 2020-02-19 | — | — | EP | disclosed |
| EP-3266834-B1 | UNIVERSAL PIGMENT PREPARATION | EVONIK DEGUSSA GMBH (DE) | 2019-02-20 | — | — | EP | disclosed |
| EP-3325423-A1 | NOVEL SHRINKAGE-REDUCING AGENTS FOR MINERAL BINDERS | Evonik Degussa GmbH (DE) | 2018-05-30 | — | — | EP | disclosed |
| EP-3266834-A1 | UNIVERSAL PIGMENT PREPARATION | Evonik Degussa GmbH (DE) | 2018-01-10 | — | — | EP | disclosed |
| WO-2017174272-A1 | PROCESSING BASE-CATALYSED ALKOXYLATION PRODUCTS | EVONIK DEGUSSA GMBH (DE) | 2017-10-12 | — | — | WO | disclosed |
| EP-3228649-A1 | TREATMENT OF ALKOXYLATION PRODUCTS OBTAINED BY ALKALINE CATALYSIS | Evonik Degussa GmbH (DE) | 2017-10-11 | — | — | EP | disclosed |
| EP-0050784-B1 | POLYURETHANES CONTAINING ECTOPARASECTICIDES | BAYER AG (DE) | 1985-04-03 | — | — | EP | disclosed |
| EP-0050782-B1 | PET COLLARS CONTAINING ECTOPARASITICIDES | BAYER AG (DE) | 1985-04-03 | — | — | EP | disclosed |
| EP-0132714-A2 | Process for the preparation of quinolines | BASF Aktiengesellschaft (DE) | 1985-02-13 | — | — | EP | disclosed |
| EP-0047419-B1 | PROCESS FOR THE PRODUCTION OF LIQUID MIXTURES OF COMPOUNDS HAVING ISOCYANATE GROUPS, AND THEIR USE AS COMPONENTS IN THE PRODUCTION OF POLYURETHANE PLASTICS MATERIAL | BAYER AG (DE) | 1984-04-18 | — | — | EP | disclosed |
| EP-0022999-B1 | CORROSION INHIBITING COMPOSITION FOR ALUMINIUM AND ALUMINIUM ALLOYS | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-03-23 | — | — | EP | disclosed |
| EP-0047419-A1 | Process for the production of liquid mixtures of compounds having isocyanate groups, and their use as components in the production of polyurethane plastics material | BAYER AG (DE) | 1982-03-17 | — | — | EP | disclosed |
| EP-0022999-A1 | Corrosion inhibiting composition for aluminium and aluminium alloys | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-01-28 | — | — | EP | disclosed |