Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212578 | 0.86 | CYP2D6 (0.45) | MAOASLC6A2AOC3MAOBHTR2A | |
| SCHEMBL6685035 | 0.82 | L3MBTL1 (0.48) | L3MBTL1MEN1KMT2ASIGMAR1MAOA | |
| SCHEMBL11047843 | 0.80 | L3MBTL1 (0.47) | L3MBTL1MEN1KMT2ASIGMAR1MAOA | |
| SCHEMBL28737092 | 0.78 | L3MBTL1 (0.45) | L3MBTL1MEN1KMT2ASIGMAR1MAOA | |
| SCHEMBL28882516 | 0.78 | FAAH (0.46) | L3MBTL1MEN1KMT2ASIGMAR1MAOA | |
| SCHEMBL3797223 | 0.78 | TAAR1 (0.56) | L3MBTL1MEN1KMT2ASIGMAR1MAOA | |
| SCHEMBL3804525 | 0.78 | POLB (0.49) | L3MBTL1MEN1KMT2ASIGMAR1MAOA | |
| SCHEMBL1678141 | 0.78 | MEN1 (0.46) | L3MBTL1MEN1KMT2ASIGMAR1MAOA | |
| SCHEMBL6286868 | 0.77 | TAAR1 (0.48) | L3MBTL1MEN1KMT2ASIGMAR1MAOA | |
| Bromide SCHEMBL11133528 | 0.77 | SLC6A2 (0.54) | L3MBTL1MEN1KMT2ASIGMAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |