Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | CTSG | P08311 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496789 | 0.86 | SMN1; SMN2 (0.81) | EPHX2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL27389698 | 0.83 | EPHX2 (0.65) | EPHX2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL27790062 | 0.83 | EPHX2 (0.65) | EPHX2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL6204191 | 0.81 | EPHX2 (0.63) | EPHX2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL19303136 | 0.81 | EPHX2 (0.63) | EPHX2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL10722901 | 0.81 | EPHX2 (0.73) | EPHX2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL10099587 | 0.81 | EPHX2 (0.63) | EPHX2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL27467294 | 0.80 | EPHX2 (0.61) | EPHX2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL17225741 | 0.80 | SMN1; SMN2 (0.77) | EPHX2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL10137831 | 0.79 | SMN1; SMN2 (0.67) | EPHX2SMN1; SMN2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |