Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NAAA | Q02083 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | CTSG | P08311 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27467294 | 0.89 | EPHX2 (0.61) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10099587 | 0.87 | EPHX2 (0.63) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL496789 | 0.84 | SMN1; SMN2 (0.81) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10912509 | 0.83 | NPC1 (0.57) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27389698 | 0.81 | EPHX2 (0.65) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27790062 | 0.81 | EPHX2 (0.65) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8851563 | 0.81 | EPHX2 (0.65) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6204191 | 0.80 | EPHX2 (0.63) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10722901 | 0.80 | EPHX2 (0.73) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8053368 | 0.79 | EPHX2 (0.54) | EPHX2NPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144393-A1 | 2-SUBSTITUTED 5-(PHENYL)-1,2-DIHYDRO-3H-3-BENZAZEPINE-3-CARBOXAMIDE DERIVATIVES AS BRD4 INHIBITORS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-08-31 | — | — | WO | disclosed |