Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MGMT | P16455 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11045282 | 0.86 | DAPK1 (0.44) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 | |
| SCHEMBL10663243 | 0.85 | DAPK1 (0.43) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 | |
| SCHEMBL10659904 | 0.82 | SMN1; SMN2 (0.43) | ALDH1A1TSHRHSD17B10MAPK1KDM4E | |
| SCHEMBL10661971 | 0.81 | SLC29A1 (0.41) | ALDH1A1TSHRHSD17B10KDM4ELMNA | |
| SCHEMBL10661136 | 0.81 | SMN1; SMN2 (0.50) | MAPK1KDM4EGAAPDE10A | |
| SCHEMBL8851197 | 0.80 | ALDH1A1 (0.55) | ALDH1A1TSHRHSD17B10MAPK1KDM4E | |
| SCHEMBL8851335 | 0.80 | PDE4A (0.55) | ALDH1A1TSHRKDM4ELMNAGAA | |
| SCHEMBL8851149 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 | |
| SCHEMBL11046569 | 0.79 | TSHR (0.49) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 | |
| SCHEMBL11046542 | 0.79 | ALDH1A1 (0.49) | ALDH1A1TSHRHSD17B10ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |