Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAPK1 | P53355 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851584 | 0.86 | ALDH1A1 (0.57) | DAPK1ALDH1A1TSHRMAPK1ALOX15 | |
| SCHEMBL10663243 | 0.85 | DAPK1 (0.43) | DAPK1ALDH1A1TSHRMAPK1ALOX15 | |
| SCHEMBL10663466 | 0.80 | ALDH1A1 (0.44) | ALDH1A1TSHRMAPK1GAAHIF1A | |
| SCHEMBL10659701 | 0.80 | PDE4A (0.50) | ALDH1A1HRH4SMN1; SMN2LMNAHPGD | |
| SCHEMBL11050386 | 0.79 | ALDH1A1 (0.44) | DAPK1ALDH1A1TSHRMAPK1ALOX15 | |
| SCHEMBL11050390 | 0.79 | SLC29A1 (0.38) | DAPK1ALDH1A1TSHRMAPK1ALOX15 | |
| SCHEMBL10659798 | 0.79 | ACHE (0.38) | ALDH1A1TSHRGAAHIF1APKM | |
| SCHEMBL11047372 | 0.78 | ACHE (0.49) | ALDH1A1TSHRMAPK1SMN1; SMN2LMNA | |
| SCHEMBL10666608 | 0.78 | POLB (0.46) | ALDH1A1TSHRMAPK1HSD17B10GAA | |
| SCHEMBL10972686 | 0.76 | HRH4 (0.43) | DAPK1MAPK1HRH4PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |