Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27299209 | 0.80 | CA1 (0.33) | CA1CA2ALDH1A1IDO1HSD17B10 | |
| SCHEMBL28326264 | 0.78 | ALDH1A1 (0.31) | CA1CA2ALDH1A1HSD17B10MEN1 | |
| SCHEMBL27439415 | 0.74 | APP (0.42) | ALDH1A1HSD17B10KDM4EMEN1LMNA | |
| SCHEMBL2319629 | 0.74 | CA1 (0.30) | CA1CA2 | |
| SCHEMBL249997 | 0.72 | CES1 (0.45) | CA1CA2ALDH1A1IDO1HSD17B10 | |
| SCHEMBL29385734 | 0.72 | CES1 (0.45) | CA1CA2ALDH1A1IDO1HSD17B10 | |
| SCHEMBL7214854 | 0.72 | ALDH1A1 (0.38) | CA1CA2ALDH1A1IDO1HSD17B10 | |
| SCHEMBL30862184 | 0.71 | CES1 (0.43) | CA1CA2ALDH1A1IDO1HSD17B10 | |
| SCHEMBL30676949 | 0.71 | CES1 (0.43) | CA1CA2ALDH1A1IDO1HSD17B10 | |
| Hydrochloric Acid SCHEMBL2710070 | 0.71 | MEN1 (0.43) | CA1CA2ALDH1A1IDO1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148537-B2 | Substituted acetophenones useful as PDE4 inhibitors | LEO PHARMA A/S (DK) | 2012-04-03 | — | — | US | claimed |
| EP-2125736-B1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA AS (DK) | 2011-03-30 | — | — | EP | claimed |
| US-20100035908-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA (DK) | 2010-02-11 | — | — | US | claimed |
| CN-101611005-A | Be used as the acetophenones of the replacement of PDE4 inhibitor | LEO PHARMA AS (DK) | 2009-12-23 | — | — | CN | claimed |
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | claimed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | claimed |
| CN-106414391-B | Method by making aromatic systems Direct Electrochemistry amination that is unactivated or deactivating on boron-doped diamond anode to prepare 1,5- diaminonaphthalene and 1- amino -5- nitronaphthalene | 科思创德国股份有限公司 | 2019-08-30 | — | — | CN | disclosed |
| CN-110023277-A | Compound, resin, composition and corrosion-resisting pattern forming method and circuit pattern forming method | 三菱瓦斯化学株式会社 | 2019-07-16 | — | — | CN | disclosed |
| CN-109942637-A | Metal complex, organic electroluminescence device | 北京诚志永华显示科技有限公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-109715592-A | Compound, resin, composition and pattern forming method | 三菱瓦斯化学株式会社 | 2019-05-03 | — | — | CN | disclosed |
| CN-109476576-A | Compound, resin, composition, resist pattern forming method, and circuit pattern forming method | 三菱瓦斯化学株式会社 | 2019-03-15 | — | — | CN | disclosed |
| CN-109476575-A | Compound, resin, composition and corrosion-resisting pattern forming method and circuit pattern forming method | 三菱瓦斯化学株式会社 | 2019-03-15 | — | — | CN | disclosed |
| CN-106414391-A | Method for producing 1.5-diaminonaphthalene and 1-amino-5-nitronaphthalene by direct electrochemical amination of non-activated or deactivated aromatic systems on boron-doped diamond anodes | 科思创德国股份有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-1217940-C | Naphthol derivatives | UENO SEIYAKU OYO KENKYUJO KK (JP) | 2005-09-07 | — | — | CN | disclosed |
| CN-1616592-A | White light-emitting compound, process for producing the same, and luminescent element utilizing the same | HIROSE ENGINEERING CO LTD (JP) | 2005-05-18 | — | — | CN | disclosed |
| CN-1401631-A | Bis (amino carbonylnaphthol) derivs. | AGANO PHARMACEUTICAL APPLIC I (JP) | 2003-03-12 | — | — | CN | disclosed |
| CN-1098316-C | Bisazo compounds and process for the preparation thereof | UENO SEIYAKU OYO KENKYUJO KK (JP) | 2003-01-08 | — | — | CN | disclosed |
| CN-1386120-A | Naphthol derivatives | UENO SEIYAKU OYO KENKYUJO KK (JP) | 2002-12-18 | — | — | CN | disclosed |
| CN-1090205-C | Condensed ring azo compound, process for producing the same and use thereof | UENO SEIYAKU OYO KENKYUJO KK (JP) | 2002-09-04 | — | — | CN | disclosed |
| CN-1226911-A | Condensed ring azo compound and process for producing the same | UENO SEIYAKU OYO KENKYUJO KK (JP) | 1999-08-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035908-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE3B | CA1 1828/4885CA2 364/4885ALDH1A1 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.