Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 4/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8853850 | 0.87 | CA12 (0.50) | PPARGPPARAMAPTKDM4EHDAC3 | |
| SCHEMBL5846805 | 0.82 | ALDH1A1 (0.47) | PPARGPPARAMAPTKDM4EHDAC3 | |
| SCHEMBL617014 | 0.80 | MAPT (0.52) | PPARGPPARAMAPTSRD5A2CA1 | |
| SCHEMBL16808276 | 0.78 | ALDH1A1 (0.44) | MAPTKDM4ECA12CA1CA2 | |
| SCHEMBL7158402 | 0.78 | PPARG (0.47) | PPARGPPARAATMCA12CA1 | |
| SCHEMBL4929134 | 0.77 | THRB (0.53) | MAPTMAPK1KDM4ETHRBATM | |
| SCHEMBL7313886 | 0.77 | THRB (0.53) | MAPTMAPK1KDM4ETHRBATM | |
| SCHEMBL15149335 | 0.77 | MIF (0.48) | PPARGPPARAMAPTMAPK1CA12 | |
| SCHEMBL3025161 | 0.76 | HDAC3 (0.54) | MAPTMAPK1KDM4ETHRBATM | |
| SCHEMBL3025158 | 0.76 | HDAC3 (0.54) | MAPTMAPK1KDM4ETHRBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681838-A | ALSO FOR SUPPRESSING CANCER CELL METASTASES AND BINDING OF OSTEOCLASTS TO BONE SURFACES | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-28 | — | — | US | disclosed |