Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL355374 | 0.87 | ALDH1A1 (0.37) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL885407 | 0.83 | ALDH1A1 (0.35) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3648974 | 0.80 | MEN1 (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL353277 | 0.75 | KMT2A (0.36) | RAB9AALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL353276 | 0.75 | KMT2A (0.36) | RAB9AALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL354665 | 0.74 | ALDH1A1 (0.34) | RAB9AALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL885466 | 0.73 | ROCK2 (0.53) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL353960 | 0.73 | HTT (0.36) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL352427 | 0.73 | SMN1; SMN2 (0.35) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19119454 | 0.73 | ALDH1A1 (0.33) | RAB9AALDH1A1SMN1; SMN2KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | claimed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | disclosed |