SCHEMBL8854971

SCHEMBL8854971

CC(C)c1c(/C=C/C#N)c(-c2ccc(F)cc2)c(OCc2ccccc2)c2c1CC(C)(C)O2

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.31
GYS1 P13807 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9084506 0.91 SQOR (0.37)
SCHEMBL9410840 0.89 SYK (0.33)
SCHEMBL8855016 0.87 CCNB2 (0.35) MAOBGYS1
SCHEMBL8855046 0.87 AR (0.36) MAOBGYS1
SCHEMBL9086388 0.84 SQOR (0.30)
SCHEMBL8854959 0.82 MAOB (0.34) MAOBGYS1
SCHEMBL9722383 0.82 MAOB (0.33) MAOB
SCHEMBL8854969 0.81 HMGCR (0.48)
SCHEMBL8855026 0.81 HMGCR (0.36) GYS1
SCHEMBL8854944 0.81 GCGR (0.36) MAOBGYS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5599952-A A 4-FLUOROBIPHENYL DERIVATIVE FUJIREBIO INC. (JP) 1997-02-04 US disclosed
US-5523460-A ANTICHOLESTEROL AGENTS FUJIREBIO INC. (JP) 1996-06-04 US disclosed
US-5481009-A Methods of producing carboxylic acid ester derivatives and intermediates for use in the methods FUJIREBIO INC. (JP) 1996-01-02 US disclosed
EP-0643054-A2 Methods of producing carboxylic acid ester derivatives and intermediates for use in the methods FUJIREBIO Inc. (JP) 1995-03-15 EP disclosed
EP-0617000-A2 4-Fluorobiphenyl derivatives FUJIREBIO Inc. (JP) 1994-09-28 EP disclosed