SCHEMBL8855342

SCHEMBL8855342

COc1cccc2c1CCC1=C(C)C(=O)CCC12C

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.61
CYP3A4 P08684 2/20 0.61
SRD5A1 P18405 3/20 0.46
SRD5A2 P31213 3/20 0.46
MAPT P10636 1/20 0.45
HPGD P15428 2/20 0.38
KDM4E B2RXH2 1/20 0.38
GLA P06280 1/20 0.38
GAA P10253 1/20 0.38
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
ACHE P22303 1/20 0.35
PARP1 P09874 1/20 0.34
AADAT Q8N5Z0 1/20 0.33
CYP19A1 P11511 1/20 0.33
CHRM2 P08172 2/20 0.33
CHRM1 P11229 2/20 0.33
CHRM3 P20309 2/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10486968 0.75 ALDH1A1 (0.38) ALDH1A1CYP3A4SRD5A1LMNACHRM2
SCHEMBL5517358 0.72 CYP3A4 (0.44) ALDH1A1CYP3A4SRD5A1GAALMNA
SCHEMBL14494031 0.72 CYP3A4 (0.44) ALDH1A1CYP3A4SRD5A1GAALMNA
SCHEMBL14494020 0.72 CYP3A4 (0.44) ALDH1A1CYP3A4SRD5A1GAALMNA
SCHEMBL6249460 0.71 SRD5A1 (0.44) ALDH1A1CYP3A4SRD5A1MAPTKDM4E
SCHEMBL8855166 0.71 ALDH1A1 (0.33) ALDH1A1CYP3A4HPGDKDM4E
SCHEMBL12260114 0.66 ALDH1A1 (0.51) ALDH1A1CYP3A4SRD5A1SRD5A2MAPT
SCHEMBL11456004 0.66 CYP3A4 (0.41) CYP3A4MAPTCYP19A1
SCHEMBL11456003 0.66 CYP3A4 (0.41) CYP3A4MAPTCYP19A1
SCHEMBL20478854 0.65 ALDH1A1 (0.53) ALDH1A1CYP3A4SRD5A1SRD5A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5654343-A NITRIC OXIDE SYNTHESIS INHIBITOR; TREATING ENDOTOXIC SHOCK OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-08-05 US disclosed
EP-0676196-A1 NITROGEN MONOXIDE SYNTHESIS INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-10-11 EP disclosed