SCHEMBL8856036

SCHEMBL8856036

O=C(O)C=CCc1ccc(F)cc1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.43
ALDH1A1 P00352 3/20 0.42
GAA P10253 2/20 0.42
LMNA P02545 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CTBP2 P56545 1/20 0.42
MEN1 O00255 1/20 0.40
POLB P06746 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
FFAR1 O14842 1/20 0.40
HTT P42858 1/20 0.40
HSD11B1 P28845 1/20 0.39
PTGER1 P34995 1/20 0.39
PTGER4 P35408 1/20 0.39
PTGER3 P43115 1/20 0.39
PTGER2 P43116 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27723025 1.00 TRPA1 (0.43) TRPA1ALDH1A1GAALMNASMN1; SMN2
SCHEMBL11366685 0.89 MAOB (0.46) ALDH1A1LMNAPTGER4PTGER3PTGER2
SCHEMBL11219683 0.83 LPAR2 (0.42) ALDH1A1GAALMNAMAPTFFAR1
SCHEMBL11219685 0.83 LPAR2 (0.42) ALDH1A1GAALMNAMAPTFFAR1
SCHEMBL23189187 0.83 CTBP2 (0.42) TRPA1ALDH1A1GAASMN1; SMN2CTBP2
SCHEMBL8219242 0.83 BCL2L1 (0.42) TRPA1ALDH1A1GAALMNASMN1; SMN2
SCHEMBL3119857 0.82 CA2 (0.50) ALDH1A1GAACTBP2MAPTKMT2A
SCHEMBL1160962 0.82 CA2 (0.50) ALDH1A1GAACTBP2MAPTKMT2A
SCHEMBL1160961 0.82 CA2 (0.50) ALDH1A1GAACTBP2MAPTKMT2A
SCHEMBL2555173 0.81 MAOB (0.61) ALDH1A1LMNAPTGER4PTGER3PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5675034-A Process for preparing 2-(p-fluorophenyl)-2 methyl-propionic acid and 3-(p-fluorophenyl)-2-methylpropionic acid derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1997-10-07 US disclosed