Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT2 | O75908 | 1/20 | 0.52 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 10/20 | 0.50 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.48 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.48 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.48 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.48 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.48 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.48 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.48 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.48 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.48 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.48 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.48 |
| ▸ | PSMA6 | P60900 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856194 | 1.00 | SOAT2 (0.52) | SOAT2SOAT1FAAHPSMB11PSMA7 | |
| SCHEMBL8856432 | 0.86 | CNR1 (0.52) | SOAT2SOAT1FAAHPSMB11PSMA7 | |
| SCHEMBL8856435 | 0.86 | CNR1 (0.52) | SOAT2SOAT1FAAHPSMB11PSMA7 | |
| SCHEMBL8856132 | 0.86 | SOAT2 (0.50) | SOAT2SOAT1FAAHPSMB11PSMA7 | |
| SCHEMBL8856135 | 0.86 | SOAT2 (0.50) | SOAT2SOAT1FAAHPSMB11PSMA7 | |
| SCHEMBL8856329 | 0.86 | SOAT2 (0.50) | SOAT2SOAT1FAAHPSMB11PSMA7 | |
| SCHEMBL8856241 | 0.78 | LMNA (0.47) | LMNAPOLBKDM4EALDH1A1GAA | |
| SCHEMBL8993787 | 0.76 | SOAT2 (0.64) | SOAT2SOAT1FAAHPSMB11PSMA7 | |
| SCHEMBL454376 | 0.73 | SOAT2 (0.62) | SOAT2SOAT1FAAHPSMB11PSMA7 | |
| SCHEMBL8856361 | 0.73 | TRPV1 (0.37) | SOAT1LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |