Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | CASP3 | P42574 | 2/20 | 0.79 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.79 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.79 |
| ▸ | APAF1 | O14727 | 1/20 | 0.79 |
| ▸ | TDP2 | O95551 | 1/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | THRB | P10828 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856654 | 0.88 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT | |
| SCHEMBL8856709 | 0.87 | KMT2A (0.79) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT | |
| SCHEMBL8856739 | 0.86 | KMT2A (0.77) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT | |
| SCHEMBL8856632 | 0.86 | KMT2A (0.77) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT | |
| SCHEMBL8856828 | 0.83 | SENP6 (1.00) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT | |
| SCHEMBL8856794 | 0.82 | SENP6 (1.00) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT | |
| SCHEMBL8856780 | 0.81 | MAPT (0.68) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT | |
| SCHEMBL8856430 | 0.81 | KMT2A (0.63) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT | |
| SCHEMBL8856682 | 0.80 | SENP6 (0.68) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT | |
| SCHEMBL9004670 | 0.80 | MAPT (0.55) | SMN1; SMN2ALDH1A1KMT2ASENP6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648381-A | Derivatives of indan-1,3-dione and indan-1,2,3-trione, methods of preparing them and therapeutic use thereof | INNOTHERA (FR) | 1997-07-15 | — | — | US | disclosed |
| EP-0566446-B1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA LAB SA (FR) | 1996-02-07 | — | — | EP | disclosed |
| EP-0566446-A1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA (FR) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993020046-A1 | INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR PREPARATION OF SAME AND THEIR USE AS THERAPEUTIC AGENTS | INNOTHERA (FR) | 1993-10-14 | — | — | WO | disclosed |