Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9814140 | 0.77 | PARP1 (0.49) | CA1CA2ADRA1A | |
| SCHEMBL8857004 | 0.76 | ADRA1A (0.43) | CA1CA2ADRA1A | |
| SCHEMBL10751929 | 0.76 | ADRA1A (0.40) | CA1CA2ADRA1ATAS1R3TAS1R1 | |
| SCHEMBL9814134 | 0.75 | CA1 (0.51) | CA1CA2HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL8857197 | 0.74 | NPSR1 (0.42) | CA1CA2ADRA1AMEN1KMT2A | |
| SCHEMBL7101744 | 0.73 | ADRA2A (0.48) | CA1CA2ADRA2AADRA1AMEN1 | |
| SCHEMBL8856947 | 0.73 | ADRA1A (0.74) | ADRA2AADRA1AMEN1ALOX15KMT2A | |
| Hydrochloric Acid SCHEMBL7104810 | 0.72 | ADRA2A (0.48) | CA1CA2ADRA2AADRA1AMEN1 | |
| SCHEMBL7098679 | 0.72 | ADRA2A (0.48) | ADRA2AADRA1AMEN1ALOX15KMT2A | |
| SCHEMBL20478812 | 0.70 | ADRA1A (0.49) | ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610174-A | Use of α1A -selective adrenoceptor agonists for the treatment of urinary incontinence | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-03-11 | — | — | US | disclosed |
| US-4634705-A | Adrenergic amidines | ABBOTT LABORATORIES (US) | 1987-01-06 | — | — | US | disclosed |