Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8857576 | 0.93 | HTT (0.42) | HTTUSP2XBP1SMN1; SMN2MAPT | |
| SCHEMBL8857623 | 0.86 | KDM4E (0.43) | HTTUSP2XBP1SMN1; SMN2MAPT | |
| SCHEMBL8857368 | 0.83 | HTT (0.43) | HTTUSP2XBP1SMN1; SMN2MAPT | |
| Bromide SCHEMBL8857645 | 0.82 | TNF (0.36) | ALDH1A1 | |
| SCHEMBL8857591 | 0.79 | KDM4E (0.44) | HTTUSP2XBP1SMN1; SMN2MAPT | |
| SCHEMBL8857586 | 0.79 | POLB (0.46) | HTTUSP2XBP1SMN1; SMN2MAPT | |
| SCHEMBL8857555 | 0.78 | HTT (0.45) | HTTUSP2XBP1SMN1; SMN2MAPT | |
| SCHEMBL8857548 | 0.76 | ACHE (0.47) | — | |
| SCHEMBL8857315 | 0.74 | PNP (0.49) | HTTUSP2XBP1SMN1; SMN2MAPT | |
| Bromide SCHEMBL8857813 | 0.74 | TNF (0.41) | HTTMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658917-A | ANTIINFLAMMATION AGENT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5648353-A | INFLAMMATORY EDEMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-15 | — | — | US | disclosed |
| US-5624926-A | Piperidinyl-dioxoquinazolines as adenosine reuptake inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| US-5605900-A | USEFUL FOR TREATMENT OF INFLAMMATORY EDEMA, ISCHEMIA AND REPERFUSION DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| EP-0638567-A1 | ADENOSINE INCORPORATION INHIBITOR | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1995-02-15 | — | — | EP | disclosed |