Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 14/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19468736 | 0.96 | CHKA (0.68) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL1108048 | 0.81 | CHKA (1.00) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| Bromide SCHEMBL5907737 | 0.80 | CYP2D6 (0.49) | — | |
| Hydrochloric Acid SCHEMBL580650 | 0.79 | CHKA (0.96) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| Bromide SCHEMBL8857808 | 0.79 | CHKA (0.57) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| Bromide SCHEMBL8857714 | 0.79 | TP53 (0.58) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| Fluoride Ion SCHEMBL126023 | 0.78 | CHKA (0.93) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| Fluoride Ion SCHEMBL126024 | 0.78 | CHKA (0.93) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL10445050 | 0.78 | CYP2D6 (0.50) | ALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL11580882 | 0.77 | TP53 (0.44) | CHKAALDH1A1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607815-A | CONTAINING ARYLHYDRAZIDE COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1997-03-04 | — | — | US | claimed |
| US-5384232-A | Process for rapid access development of silver halide films using pyridinium as development accelerators | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-01-24 | — | — | US | claimed |
| US-5607815-A | CONTAINING ARYLHYDRAZIDE COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1997-03-04 | — | — | US | disclosed |