Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mequinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | S100B | P04271 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mequinol SCHEMBL8333032 | 0.77 | ESR2 (0.48) | LTA4HESR2APPCALM1GAA | |
| Mequinol SCHEMBL6037354 | 0.76 | ESR2 (0.67) | LTA4HESR2APPCALM1GAA | |
| SCHEMBL2865073 | 0.73 | CLK4 (0.38) | KMT2AMAPTMEN1NPC1KDM4E | |
| Mequinol SCHEMBL1535640 | 0.73 | ESR2 (0.84) | LTA4HESR2APPCALM1GAA | |
| SCHEMBL251722 | 0.73 | HSP90AA1 (0.38) | — | |
| Mequinol SCHEMBL21009 | 0.73 | — | — | |
| 1,4-Dimethoxybenzene SCHEMBL8351066 | 0.73 | ESR2 (0.84) | LTA4HESR2APPCALM1GAA | |
| Mequinol SCHEMBL166535 | 0.73 | ESR2 (0.84) | LTA4HESR2APPCALM1GAA | |
| Mequinol SCHEMBL28829427 | 0.71 | ESR2 (0.73) | LTA4HESR2APPCALM1GAA | |
| Mequinol SCHEMBL20696082 | 0.71 | ESR2 (0.80) | LTA4HESR2APPCALM1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698374-A | Process for the formation of an image through adhesion of particulate image forming material | FUJI PHOTO FILM CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |