Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6318042 | 0.91 | TDP1 (0.44) | TDP1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6322156 | 0.90 | TDP1 (0.43) | TDP1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6317889 | 0.89 | TDP1 (0.46) | TDP1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6317940 | 0.89 | TDP1 (0.45) | TDP1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6318373 | 0.87 | TDP1 (0.55) | TDP1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6323227 | 0.85 | KMT2A (0.60) | NPC1RAB9AHPGDSMN1; SMN2HTT | |
| SCHEMBL6324336 | 0.84 | NPC1 (0.47) | TDP1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6315847 | 0.84 | ALDH1A1 (0.49) | TDP1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL885646 | 0.83 | CA1 (0.39) | RAB9ASMN1; SMN2TSHRACACBMLYCD | |
| SCHEMBL885451 | 0.82 | CA1 (0.52) | TSHRACACBMLYCDLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197633-A1 | N-Alkyl-Heterocyclyl Carboxamide Derivatives | BAYER CROPSCIENCE S.A. (FR) | 2010-08-05 | — | — | US | claimed |
| EP-1937637-A1 | NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039615-A1 | NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2007-04-12 | — | — | WO | claimed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | claimed |
| CN-1549714-A | Aminoisoxazole derivatives active as kinase inhibitors | — | 2004-11-24 | — | — | CN | claimed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | claimed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | claimed |
| US-8148538-B2 | N-alkyl-heterocyclyl carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2012-04-03 | — | — | US | disclosed |
| US-20100197633-A1 | N-Alkyl-Heterocyclyl Carboxamide Derivatives | BAYER CROPSCIENCE S.A. (FR) | 2010-08-05 | — | — | US | disclosed |
| EP-1937637-A1 | NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039615-A1 | NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2007-04-12 | — | — | WO | disclosed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | TDP1 527/4885NPC1 3741/4885RAB9A 1754/4885 |
| US-20100197633-A1 | N-Alkyl-Heterocyclyl Carboxamide Derivatives | CYP1A2, CYP3A7, GANC | TDP1 2550/4885NPC1 659/4885RAB9A 1635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.